A 2016 study in the Journal of Clinical Pharmacy and Therapeutics finds that the combination of memantine (Namenda), a drug used to treat Alzheimer’s disease, and the antidepressant sertraline (Zoloft) improved unipolar depression more than sertraline plus placebo.. At this point, adding memantine to Ms. A’s regimen of clomipramine (300 mg/day) and sulpiride (400 mg/day) was suggested, and she signed informed consent after explanation of this off-label therapy. Alternatives to Memantine for Depression. It is approved for the treatment of Alzheimer’s disease and recent studies have investigated its utility in the treatment of other psychiatric disorders. Dr Andrade takes a closer look at the methods the authors used and the studies they included to weigh the merits of their conclusions. Take one dose every day, at the same time of day each day. Memantine as a mood stabilizer. Memantine is a prescription drug. Memantine partially blocks N-methyl-D-aspartate (NMDA) receptors' glutamate channels located in the CNS. Memantine did not improve the treatment efficacy for depressive symptoms in MDD and BD patients. 3. In turn, depression may hinder a patient's recovery from an illness. Memantine oral tablet is … It is taken by mouth. Side effects requiring immediate medical attention. Memantine may be useful for treating substance abuse and dependence. Memantine is a medication used to treat moderate-to-severe Alzheimer's disease. Your doctor will need to check your progress while you are using memantine. This study will evaluate the effectiveness of memantine in improving rehabilitation outcomes and preventing major depressive disorder in older adults who have been admitted to a rehabilitation hospital for a hip fracture or a cardiopulmonary condition. » novelagent, posted by SLS on July 11, 2012, at 6:47:14. Depression remission rates were 79.4% in the memantine group and 62.1% in the placebo group, which was not a statistically significant difference. This paper evaluates memantine as an augmentation therapy for treatment of anxiety. In fact, memantine (5 mg/kg) significantly potentiated this deficit. Clinical trials of memantine in depression Use of memantine with minimal side effects and drug interaction seems reasonable in the elderly but its antidepressant activity is controversial. Ms. Memantine is a non-competitve NMDA receptor antagonist, but, at variance with the most potent NMDA receptor blockers, such as Ke tamine, Phencyclidine and MK-801, has a low ... conditions, including depression, with conflict ing and inconclusive results (Zdanis & Tampi, 2008). Scott, I take it you were only on the starting dose of 5mg then-- Aricept is dosed at 5mg for 3 months before it's raised to 10mg. Objective . The doses of memantine were flexible and ranged from 5 to 20 mg/day. This has been used for improved mood for thousands of years. Patients, ages 18 to 80, with a diagnosis of major depression (without psychotic features), will be randomized to double-blind treatment outpatient study to receive either memantine (5-20mg/day) or placebo for a period of 8 weeks. Memantine is a dissociative, particularly during the startup phase, so it's not surprising that you would feel distanced from anxiety and depression. It comes in three forms: immediate-release tablet, oral solution, and extended-release capsule. The drug, memantine, acts on the brain’s NMDA receptors – those known to play a role in treating depression. This will gradually be increased over the following few weeks. Use memantine regularly to get the most benefit. Memantine for depression. Keep the liquid medicine bottle tightly closed with the cap provided. However, treatment may be continued in primary care under a shared-care protocol. Posted by novelagent on July 11, 2012, at 17:56:45. Memantine hydrochloride 20 mg film-coated tablets contain 20 mg memantine hydrochloride equivalent to 16.62 mg memantine. The other ingredients are microcrystalline cellulose, croscarmellose sodium, colloidal anhydrous silica and This finding is the basis for the minimal side effect profile displayed by memantine. Memantine was started at 5 mg/day and titrated to 20 mg/day within 2 weeks. Along with its needed effects, memantine may cause some unwanted effects. Memantine has been associated with a moderate decrease in clinical deterioration with only a small positive effect on cognition, mood, behavior, and the ability to perform daily activities in moderate to severe Alzheimer's disease. Fifty-five percent of the patients had type I bipolar disorder, and 45% had bipolar II disorder. Memantine helps to ease the symptoms of dementia in Alzheimer's disease. 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